Retatrutide¶
Important disclaimer
This page is for educational purposes only. Always consult a licensed doctor, get baseline blood work, and proceed at your own risk.
Why Retatrutide Is Creating So Much Hype¶
In simple terms
Retatrutide is the world’s first triple agonist → GLP-1 + GIP + Glucagon all in one molecule.
This extra glucagon action makes your body burn more calories even while resting → the highest weight-loss numbers ever recorded in trials.
Current data (Phase 3 trials + early research users 2025):
- 22–24 % body weight at 48 weeks
- Some people hitting 28–30 % at 72 weeks
Recommended Dosing Strategy¶
Golden rule: Only increase when appetite returns → exactly like tirzepatide
Stay on the lowest dose that keeps you full and losing 0.7–1.5 kg per week.
Most people never need to go above 8 mg.
| Week | Suggested Dose (once weekly) | Rule of Thumb |
|---|---|---|
| 1–4 | 1 mg | Mandatory starting dose |
| 5–8 | 2 mg | Most early users stay here |
| 9–16 | 4 mg | Move up only if hunger returns |
| 17+ | 8 mg | Common long-term dose |
| 21+ | 12 mg | Only for very large individuals or true plateau |
Expected Timeline¶
| Time | What most people experience |
|---|---|
| Week 1–4 | Possible nausea |
| Week 5-8 | Rapid 1 kg per week, energy noticeably higher |
| Month 3–6 | 15–25 kg down, major body recomposition |
| Month 12 | 30–45+ kg total loss is becoming common |
Side Effects & How to Handle Them¶
Side effects are similar to tirzepatide but can include slight increase in heart rate
- Nausea & vomiting → start at 1 mg, inject at night
- Faster heartbeat (10–15 bpm increase) → normal, goes away after a few weeks
- Constipation/diarrhea → same fixes as others
- Mild sweating or feeling warm → glucagon effect
Heart-rate increase is usually harmless but monitor if you have heart conditions.
Blood Work You Should Get¶
| Test | When | Approx Cost (Hi-Precision) |
|---|---|---|
| CBC + Fasting Glucose + HbA1c | Baseline & every 2–3 months | ₱1200–1800 |
| Lipid panel | Baseline & every 3 months | ₱800–1200 |
| TSH + Free T4 | Baseline & every 3 months | ₱1000–1500 |
| ALT/AST + GGT (liver) | Baseline & every 2 months | ₱800–1200 |
| Resting heart rate & BP | Weekly at home | – |
Bottom line
Retatrutide is currently the strongest weight-loss peptide as of 2025.
It is newer and slightly harder to source, but the results are unmatched for people who tolerate it well.
Ready to try the triple agonist?
- Get full blood work first (especially liver & heart rate)
- Start at 1 mg and only go up when needed
- Learn how to choose suppliers
You’ve got this!