GHK-Cu (Topical)¶

Tags: GHK-Cu, Copper Peptide, Topical, Skin Regeneration

Quick Facts¶

• Typical Concentration: 0.5–2% (0.5–1% common)
• Route: Topical — face, neck, scalp
• Cycle: 12–16 weeks (typical)
• Storage: Room temperature; cool, dry place

Overview¶

GHK‑Cu is a naturally occurring copper tripeptide found in human plasma, saliva, and urine. Plasma levels decline from ~200 ng/ml at age 20 to ~80 ng/ml by age 60. Research shows it affects 31.2% of human genes and promotes wound healing, collagen synthesis, and anti‑aging effects. Topical formulations deliver copper directly to the skin for local regenerative effects; most clinical evidence for topical use is from in vitro and human skin studies.

Key Benefits¶

• Enhanced collagen and elastin production
• Improved skin elasticity and texture; reduced fine lines
• Accelerated wound healing and barrier restoration
• Hair growth stimulation when applied to scalp

Mechanism of action¶

Topical GHK‑Cu penetrates skin layers to deliver copper to target tissues, activating fibroblasts, stimulating collagen and elastin synthesis, promoting angiogenesis, and modulating inflammatory responses for skin regeneration.

Molecular information¶

• Weight: 404.96 Da
• Length: 3 amino acids
• Type: Copper tripeptide

Amino Acid Sequence:

Gly-His-Lys

Complexed with copper (Cu2+) for enhanced bioavailability.

Research indications¶

• Skin regeneration and anti‑aging
• Hair growth stimulation
• Wound healing and barrier repair
• General skin health and hydration

Research protocols¶

Timing: Apply to clean, dry skin. Morning use requires sunscreen; evening application supports overnight repair. Start once daily to assess tolerance.

Interactions¶

How to apply¶

1. Cleanse skin thoroughly with a gentle cleanser.
2. Pat skin dry and wait ~5 minutes.
3. Apply a thin, even layer of GHK‑Cu product to target areas.
4. Massage gently until fully absorbed (1–2 minutes).
5. Follow with moisturizer if using a serum; apply sunscreen during daytime use.

Quality Indicators¶

What to expect¶

• Week 1–2: Improved texture and hydration
• Week 3–4: Reduction in fine lines and increased smoothness
• Week 6–8: Improved firmness and elasticity
• Week 8–12+: Visible improvements in tone and clarity; hair growth 6–12 weeks for initial signs

Side effects & safety¶

• Patch test before first use to check for sensitivity
• May cause mild, transient irritation initially
• Use sunscreen with daytime application (photosensitivity risk)
• Avoid contact with eyes and mucous membranes
• Discontinue if severe irritation or allergic reaction occurs

References¶