Epitalon (Epithalon, Epithalamin)¶

Tags: Epitalon, Epithalon, Telomerase, Anti-aging

Overview¶

Epitalon (also called Epithalon or Epithalamin) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) modeled on a natural pineal gland peptide. Developed by Vladimir Khavinson and studied for decades, Epitalon is primarily researched as a telomerase activator with potential anti‑aging effects through telomere maintenance, melatonin regulation, and gene‑expression modulation. Note: some Western dosing recommendations may be substantially higher than doses used in original Russian studies.

Key Benefits¶

• Telomerase activation and telomere length preservation
• Enhanced melatonin production and improved sleep/circadian rhythms
• Improved immune function and markers of cellular rejuvenation
• Potential lifespan and healthspan benefits in animal studies

Mechanism of Action¶

Epitalon appears to stimulate telomerase activity at very low concentrations, modulate pineal function to increase melatonin, influence epigenetic regulation of gene expression, and support antioxidant defenses.

Molecular Information¶

• Weight: 390.35 Da
• Length: 4 amino acids
• Type: Tetrapeptide

Ala-Glu-Asp-Gly

Research Indications¶

• Anti‑aging — telomerase activation and cellular rejuvenation (Most Effective)
• Neuroprotection and circadian restoration (Effective)
• Immune function support (Moderate)
• Experimental longevity interventions (animal evidence)

Research Protocols¶

Timing: Morning dosing often aligns with cortisol rhythm; some prefer evening dosing for sleep benefits.

Interactions¶

How to Reconstitute¶

1. Clean vial tops with an alcohol swab and allow to dry.
2. Use bacteriostatic water (BAC) and sterile technique.
3. For corrected microgram dosing guidance: add 5 mL BAC water to vial to create desired concentration (example shown in source).
4. Inject water slowly down vial wall to avoid foaming.
5. Gently swirl; do not shake vigorously.
6. Use small syringes (0.3 mL) for microgram dosing accuracy.
7. Refrigerate reconstituted solution and use within recommended window (see Quality Indicators).

Quality Indicators¶

What to Expect¶

• Days 1–3: often minimal immediate effects; subtle energy or sleep changes reported
• Days 3–7: improved sleep quality, vivid dreams (melatonin effect)
• Week 2: improved morning energy and mood stability
• Weeks 3–4: skin quality and wound‑healing improvements
• Months 1–3: some laboratory markers may show telomere‑related changes after repeated cycles

Side Effects & Safety¶

• Generally well tolerated in reported clinical use
• Corrected microgram dosing reduces risk compared with high‑dose anecdotes
• Theoretical cancer concern due to telomerase activation — avoid with active malignancy
• May cause mild injection‑site reactions or vivid dreams

Quick Start¶

• Typical dose: 200–500 μg per injection (evidence‑based range)
• How often: Once daily for 10–20 days per cycle
• Where to inject: Subcutaneous — abdomen, thigh, or upper arm
• Storage: Refrigerate at 2–8°C; use reconstituted solution within recommended window
• Cycle length: 10–20 days; multi‑month breaks between cycles are common (e.g., 4–6 months)

References¶